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Below is a complete set of lyrics and credits for the album Muscles & Magnets. All songs were arranged and produced by Do Peterson and co-arranged by Greg Crowther.
Hooray For NMR Spectroscopy!
written by Greg Crowther and Do Peterson
Greg: broadcaster vocals, keyboard
Lori DeGloria: skeptic vocals
Do: keyboard, percussion, sampler
Kirk L. Van Scoyoc: scientist vocals
Backing vocalists: Tim Billo, Gina Coffman, Karen Hayes, Michelle Merklin, Levi Moore, Richard Moore, Ben Piggot, Tom Satwicz, Louise Spiegler, Liz Stahl, Peter Stoessel, John Weller
I love my magnet; it measures molecules galore,
From fat and water to ATP and many more!
I scan live people! It's noninvasive; there's no mess!
Time resolution is several seconds, sometimes less!
But there are atoms you can't see.
The ones you can are enough for me!
Hooray for NMR spectroscopy!
I love my magnet; it gives me spectra full of peaks,
And, with a standard, I'll find the numbers that I seek.
Consider this case: peak A is twice the size of B.
If B's the standard, then you know A's molarity!
I don't like all this chemistry.
It's great for scientists like me!
Hooray for NMR spectroscopy!
I love my magnet; it doesn't cause my subjects pain.
They'll gladly help me, sometimes without financial gain!
I scan their bodies -- or just one anatomic zone.
The coils and gradients let me choose muscle, brain, or bone!
Lying immobile ain't for me.
It's only for an hour or three!
Hooray for NMR spectroscopy!
Twinkle, Twinkle, T2*
traditional; scientific lyrics by Greg Crowther
Greg: backing vocals
Lori DeGloria: backing vocals
Linda Khandro: harp
Diane Mapes: keyboard
Kirk L. Van Scoyoc: backing vocals
Do: lead and backing vocals, acoustic guitar, sleigh bells
Twinkle, twinkle, T2*;
How I wonder what you are!
XY signal soon decays;
Why do the spins go out of phase?
Twinkle, twinkle, T2*;
Something pulls those spins apart.
Spin-spin crosstalk sets T2,
But by then T2* is through.
A brief duration here is sealed
By an inhomogeneous field.
Twinkle, twinkle, T2*;
Now I know just what you are!
The Phantom
written by Andrew Webber, Charles Hart, Richard Stilgoe, and Mike Batt; scientific lyrics by Greg Crowther
Craig Chin: electric guitar
Lori DeGloria: phantom vocals
Gretchen Ludwig: backing vocals
Diane Mapes: keyboard
Do: drum programming, electronics, vocoder
Kirk L. Van Scoyoc: scientist vocals
SCIENTIST: PHANTOM:
Transparent as the wind
That chills my spine,
She lurks inside the lab,
This ghost of mine.
And, buffered heavily
With PO4,
The phantom of the copper coil is there
In the magnet bore.
Each new experiment
Must be rehearsed.
Before you test a man,
You test me first.
You try your protocols
Until I’m sore.
The phantom of the copper coil is there
In the magnet bore.
I think the pulse will work...
I call your bluff.
You’re not a man, you know.
I’m close enough.
And though I wish that you And though you wish that I
Could be ignored, Could be ignored,
The phantom of the copper coil is there The phantom of the copper coil is there
In the magnet bore. In the magnet bore.
The Nucleus I Like Best
written by Greg Crowther, Do Peterson, Adam Ludwig, and Claudia McLaughlin
Craig Chin: electric guitar
Greg: rapping
Lori DeGloria: lead vocals
Adam Ludwig: rapping
Gretchen Ludwig: lead vocals
Diane Mapes: keyboard
Do: bass, drum programming, spoken vocals
Kirk L. Van Scoyoc: lead vocals, banjo
There's 15N, 39K, 19F, and also 13C,
But of all the atoms East to West, the nucleus I like best is 31P.
Proton spins are everywhere, and MRIs reveal their density.
But all that leaves me unimpressed; the nucleus I like best is 31P.
Take a limb, get it shimmed, and sample from the muscles that you see.
A spectrum lets you quantify the PCr, Pi, and ATP.
Cell pH can be deduced from the inorganic phosphate frequency;
You can likewise measure magnesium using the chemical shift of ATP.
If you scan a leg or hand during stimulation and recovery,
The spectra let you find the rates of using and creating ATP.
Now NMR can take you far beyond this type of phosphate chemistry,
But I've come clean and I've confessed -- the nucleus I like best is 31P.
La Méthode Scientifique
written by Chris Rawlings
Lori DeGloria: vocals
Diane Mapes: accordion
Do: acoustic guitar, bass, drum programming
REFRAIN:
L'avidité de savoir
Avoir la curiosité
Posez, posez, posez les questions
Observez et classifiez
Comment, comment, comment ça marche
Pensez a des questions
Posez une hypothèse
Comment verifier si elle est bonne
REFRAIN
Projetez une experience
Enregistrez les données
Si l'hypothèse est validé
On peut toujours le verifier
REFRAIN
Observez, questionnez, tout les thèses
Pensez et poser l'hypothèse,
Experimentez, enregistrez toutes les données
Les conclusions doivent être verifier
Et c'est la méthode scientifique acceptée
29 Reasons
written by Willie Dixon; scientific lyrics by Greg Crowther
Greg: lead vocals, keyboard
Lori DeGloria: backing vocals
Adam Ludwig: backing vocals
Do: backing vocals, acoustic guitar, drum programming
Kirk L. Van Scoyoc: backing vocals
I got 29 reasons why muscles are not a bore.
I got 29 reasons why muscles are not a bore.
When applying for grants,
I can find about two or three more.
If you check out a standard lass,
Muscles are a third of her body mass.
I got 29 reasons why muscles are not a bore.
When applying for grants,
I can find about two or three more.
From cooking your food to sweeping the floor,
Muscles do a really wide range of chores.
You could be out shopping or starting to groove,
But muscles are behind your every move.
I got 29 reasons why muscles are not a bore.
When applying for grants,
I can find about two or three more.
When a muscle is used at a sporting event,
Its fluxes rise 5000 percent!
And if you're getting fit or you have a disease,
Muscle adaptation can be quantified with ease.
I got 29 reasons why muscles are not a bore.
When applying for grants,
I can find about two or three more.
Myofibrils
written by Douglas Fieger and Burton Averre; scientific lyrics by Greg Crowther
Greg: lead vocals
Lori DeGloria: backing vocals
Adam Ludwig: bass
Gretchen Ludwig: backing vocals
Do: electric guitar, drum programming
Kirk L. Van Scoyoc: banjo
Ooh my little filaments, filaments --
Actin and myosin myofibrils:
Proteins that are long and dense, long and dense,
Making up the structure of the myofibrils.
CHORUS:
Signal from the brain rides the nerve to the muscle,
Where the myosin inside will slide past the actin of the
My-my-my-y-y, woo! Muh-muh-muh-myofibrils.
Add a little calcium, calcium
To the cytoplasm near the myofibrils.
It will turn troponin on, troponin on,
Causing the contraction of the myofibrils.
CHORUS
Muscles need energy, energy,
Most of which is needed by the myofibrils.
Myosin burns ATP, ATP
Fueling the contractions of the myofibrils.
CHORUS
Glucose, Glucose
written by Jeff Barry and Andy Kim; scientific lyrics by Greg Crowther
Greg: keyboard, tambourine, claps
Lori DeGloria: backing vocals
Gretchen Ludwig: backing vocals
Do: acoustic guitar, bass, drum programming, claps
Kirk L. Van Scoyoc: lead vocals
Glucose -- ah, sugar sugar --
You are my favorite fuel
From the blood-borne substrate pool.
Glucose -- monosaccharide sugar --
You're sweeter than a woman's kiss
'Cause I need you for glycolysis.
I just can't believe the way my muscles take you in.
(For you, they'll open the door.)
All it takes is a little bit of insulin
(To upregulate GLUT4).
Ah, glucose -- ah, sugar sugar --
You help me make ATP
When my predators are chasing me.
Ah, glucose -- you're an aldehyde sugar,
And you're sweeter than a woman's kiss
'Cause I need you for glycolysis.
I just can't believe the way my muscles break you down.
(My glycogen is almost gone.)
A few more seconds and I'll be rigor mortis-bound.
(Acidosis done me wrong.)
Your sweet is turning sour, baby.
I'm losing all my power, baby.
I'm gonna make your muscles ache.
No, no, no!
I'm swimming in lactate, baby.
Yes, I'm swimming in lactate, baby.
Now I'm drowning in lactate, baby.
I'm gonna make your muscles ache.
No, no, no!
I'm drowning in lactate, baby.
Ah, glucose -- ah, sugar sugar --
I used you up and you left me flat;
Now I'll have to get my kicks from fat.
Oh, glucose, glucose, sugar, sugar,
The honeymoon is over now.
Necessary But Not Sufficient
written by Greg Crowther and Do Peterson
Greg: keyboard
Lori DeGloria: backing vocals
Adam Ludwig: lead vocals, bass
Do: lead vocals, acoustic and electric guitar, drum programming
Kirk L. Van Scoyoc: backing vocals
The muscle starts to pull its load, but glucose use is slow
Because [Pi] and [ADP] and [AMP] are low.
CHORUS:
Necessary but not sufficient:
Something's there and yet something's missin',
And the textbook authors sure will be surprised.
High metabolites? Not sufficient.
Muscles pulling tight? Not sufficient.
The two must coexist for flux to rise.
Contraction ends, and once again, the glucose use subsides.
This sudden drop cannot be stopped by high metabolites.
CHORUS
The Krebs Cycle
melody and lyrics by Lynda Jones; adapted by Do Peterson and Greg Crowther
Greg: geek vocals, keyboard
Lori: lead vocals
Do: bass, hyper-dramatic vocals, keyboard, acoustic and electric guitar, drum programming
Kirk L. Van Scoyoc: banjo
Acetyl CoA combines with oxaloacetic acid
To create a citric acid. That's how it begins.
Then a water removed and added makes it isocitric acid,
Which, in turn, oxidized and loses CO2.
Then alpha-ketoglutaric is oxidized again,
Losing carbon dioxide with an NADH spin.
Then through a phosphorylation
Succinyl CoA congeals a GDP to GTP to toss back CoASH.
CHORUS:
Acetyl CoA, citric acid, iso-,
Alpha-ketoglutaric, succinyl CoA,
Succeeded by succinic, fumaric and malic,
Then oxaloacetic starts the cycle again.
Soon we see succinic acid forming a fumaric acid
As it forms an FADH2 along the way.
Water washed upon fumaric makes it into acid malic.
Now there's only one step left, so let's be on our way.
With one more oxidation, resisting degradation,
A final NADH is made and brings us to the end.
Oxaloacetic acid, first and last, a simple acid
Then accepts an acetyl CoA and starts again.
CHORUS
Come On Down (The Electron Transport Chain)
written by Greg Crowther and Do Peterson
Do: bongo drums
Kirk L. Van Scoyoc: vocals
Electron pair on NADH,
Looking for a place to go?
You could jump onto pyruvate,
But if you want to reach a lower energy state,
Why don't you come on down the electron transport chain
And take a downhill ride on this one-way train?
Oh, won't you come on down the electron transport chain?
It exploits delta G to make ATP.
Oxidative Phosphorylation
written by Greg Crowther and Do Peterson
Greg Crowther: lead vocals, claps, tambourine
Lori DeGloria: lead and backing vocals
Do Peterson: lead and backing vocals, claps, drum, acoustic guitar, chimes, melodica, keyboard
Do you see the athletes run?
Do you see the children crawl?
Every soul beneath the sun --
Ox phos fuels them one and all.
You can't see inside their cells;
If you could, here's what you'd see:
Small cigar-shaped organelles
Synthesizing ATP.
Matrix protons get pumped out
To the intermembrane space.
Then they take an inward route
Through the ATP synthase.
[Preacher's message:]
Fuel the muscles.
Feel the sunshine.
Feel the ATP.
See the children.
See the athletes.
Ox phos fuels us you and me.
In the morning,
In the mid-day,
In the afternoon.
In the evening,
In the late night,
Ox phos fuels us me and you.
When I feel up,
When I feel good,
When I'm movin' 'round,
When I sit up,
When I stand up,
When I make my sound.
All right, now.
Oxidative phosphorylation.
Oxidative phosphorylation.
Oxidative phosphorylation.
Oxidative phosphorylation....
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