ASP (Affected Sibling-Pairs)       [ previous song / next song ]

written by Do Peterson

Do: All Vocals, Acoustic and Electric Guitars, Bass, Synth and Drum Machine

Oh affected sibling pairs | Groove the background motivation | Oh affected sibling pairs | Pump the context cogitation | Oh affected sibling pairs | Pump the mental preparation | Oh affected sibling pairs | Groove the background motivation | Oh... | The distribution theory | That I mentioned in my title slide | Is direct'ly applied | To what is called linkage analysis. | The linkage analysis data | To which this distribution theory will be applied | Will come from affected sibling pairs now | Two girls, two boys or a girl and a guy. | Oh affected sibling pairs | Pairs of siblings, both affected | Oh affected sibling pairs | Pairs diseased that we've selected | Oh... | Now the kind of data | Collected from the siblings pairs | Is called genetic marker data, | Is in the form of counts of marker alleles. | Now the marker data | Identical by descent, you see. | The acronym is IBD | which means the same ancestral marker copy. | Oh affected sibling pairs | How many markers do you share | Oh affected sibling pairs | Get our marker data there | Oh affected sibling pairs | Pairs of siblings, both affected | Oh affected sibling pairs | Pairs diseased that we've selected | Oh... | Linkage analysis, | You find the place of disease genes. | The chromosome location | Or locus is what we glean. | It can be shown that markers | Shared by affected sibling pairs | More often than expected is evidence | Disease gene is near. | How much more often than expected is an amount | That can be tested. | Wešre figuring out whether or not | Our method cannot be bested. | Oh affected sibling pairs | Pairs of siblings, both affected | Oh affected sibling pairs | Pairs diseased that we've selected | Oh... | Oh affected sibling pairs